Sichuan Qingmu Pharmaceutical Co., Ltd.

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Afoxolaner Posted on: 2024-12-11 Product Details: Model Number: Afoxolaner API 001 Place of Origin: Sichuan China Brand Name: Sichuan Qingmu Pharmaceutical Co., Ltd. CAS No.: 1093861-60-9 Therapeutic Category: Anthelmintic Technology: Synthetic Dosage Form: Oral Solids Innovator Brand: NexgardFrontproand Nexgard Spectra(USA) Registration Status: DMF Polymorph: Form A GMP: FDA(USA)/NMPA(China)/MFDS(Korea) approved EHS: ISO 14001 & 45001 certified Grade: Active Pharmaceutical Ingredient(API) ChemicalName: 4-[(5R)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide Molecular Formula: C26H17ClF9N3O3 Molecular Weight: 625.87000 Specification: Enterprise Standard established according to ChP/USP/EP Appearance: Powder Purity: not less than 98% Residual Solvents: fully comply with ICH Q3C Mutagenic impurities: fully comply with ICH M8 Nitrosamine assessment: available Production capacity: Commercial Standard Package: 1kg/bag5kg/bagor according to the customer¡¯s requirement. Payment & Shipping Terms: Minimum Order Quantity: 10 Gram/Grams Delivery Time: With Stock Price Terms: USD 10~100 Any Chinese Port Payment Terms: L/C, T/T Supply Abiity: tons per Year Please login * Login Name or E-mail: * Password: Forgot login name or password?

Afoxolaner Product Description

Applications of Afoxolaner API

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• Afoxolaner (brand name NexGard®) is used to treat and control flea and tick infestations in dogs. After being ingested by a dog, afoxolaner is distributed throughout the dog’s body. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal.
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• It acts as an antagonist at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA-receptors). Isoxazolines, among the chloride channel modulators, bind to a distinct and unique target site within the insect GABA-gated chloride channels, thereby blocking the pre- and post-synaptic transfer of chloride ions across cell membranes. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines.
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Why Choose Us as Your Afoxolaner Manufacturer?

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• As an Afoxolaner manufacturer, Qingmu’s factory is established according to ICH/USFDA/EU/JAPAN/China regulations and current GMP, totally complies with environmental law in China, and no risk of removing the factory. A new API factory is under design and is predicted to be put into use in 2025.
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• Qingmu’s team has rich experience in patent challenges on crystalline form & synthesis processes and also synthetic route development and scale-up & quality research.
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• Qingmu’s lab is equipped with HPLC, GC, ICP-MS, GC-MS, CAD, microbalance, Malvern particle analyzer, etc. We also passed the site inspection from NMPA(China), FDA(USA) and MFDS(Korea) and also customer audits from Europe, USA and Japan, etc. So please rest assured to choose us as your partner.
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• Qingmu is an afoxolaner supplier, that successfully exported products to more than 40 countries including Japan, USA, Germany, Spain, the Netherlands, Russia, South Korea, and Brazil.
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About Qingmu

FAQ

Ql: Are you a manufacturer or trading company?

A1: We are a manufacturer

Q2: What certifcates do you have?

A2: We have GMP certificate issued by Chinese NMPA, EIR letter issued by USFDA, GMP certificate issued by Korean MFDS, CEP certificate, etc.

Q3: How does your factory do regarding quality control?

A3: Our factory is managed by GMP, we have our own QC lab to test the material and APIs

Q4:How about your after-sale service?

A4: We have compliant SOP as per GMP requirement and will be handled according to SOP.